casino game quest 2

fortune rabbit demo pg soft Talen Energy Corporation Announces Closing of Incremental Term Loan B Financing and Related ...

Seven Golden Knights players named to 4 Nations Face-Off rostersPENN Entertainment PENN received a Wall Street upgrade Friday on a positive outlook for both its casino and sports betting segments. The PENN Analyst: JPMorgan analyst Joseph Greff upgraded shares of Penn from Neutral to Overweight and raised the price target from $19 to $27. Read Also: PENN Entertainment Stock Climbs Despite Q3 Earnings Miss: What’s Going On? The Analyst Takeaways : Penn has a favorable risk-reward going forward, Greff said in a new investor note. The analyst said there is a sightline to the "bottoming of its regional land-based casino cashflow generation" and a path to modest growth for its retail projects. "In addition, we see reasonably set expectations for near-term Interactive (OSB and iGaming) losses for the 4Q24 and 2025 with buy-side expectations for modestly positive EBITDA generation in 2026," Greff said. Greff said ESPN Bet continues to be one of the biggest drivers for the stock. "We see a scenario of modestly positive segment EBITDA as not priced in the shares and, importantly, is not that much more than PENN's estimated annual market access fees." Penn pays Walt Disney Co DIS for the rights to the ESPN name and brand. Greff said if ESPN Bet is not profitable, the company could shut it down and "milk the $60m-ish of market access fees." The analyst said company commentary said monthly active users were up 144% year-over-year for ESPN Bet with average handle per user up 64% month-over-month. Enhancements made by Penn to further integrate the ESPN brand into the platform ahead of the NFL season look to have paid off, the analyst added. The analyst said if ESPN Bet isn't successful, there is still value of the company's land-based casinos and market access fees that sportsbooks pay the company, assigning a value of $26 for this segment. Penn's $850 million being spent in 2024 and 2025 on four retail growth projects is highlighted by the analyst, which includes replacing a riverboat facility with a land-based casino and hotel, developing a new land-based casino and adding hotels for the Hollywood Columbus and M Resort properties. "Net-net we see a favorable fundamentally driven risk-reward given improving free cash flow ... and shrinking Interactive losses." PENN Price Action: Penn stock is up 3.60% to $20.73 on Friday versus a 52-week trading range of $13.50 to $27.21. Penn stock is down 20% year-to-date in 2024. Read Next: Robinhood CEO Vlad Tenev Says Sports Betting Comments Taken ‘A Little Bit Out Of Context,’ But He Also ‘Wouldn’t Rule It Out’ Photo: Shutterstock © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.Hong Kong, Nov. 22, 2024 (GLOBE NEWSWIRE) -- Click Holdings Limited (“Click Holdings” or “we” or “us”, NASDAQ: CLIK) and its subsidiaries (collectively, the “Company”), a human resources solutions provider based in Hong Kong, announced its unaudited financial results for the six months ended June 30, 2024. In the first half of 2024, total revenue increased by approximately 14.3% We achieved steady growth over the past six months and continued to consolidate its market position in the human resources solutions sector. In the first half of 2024, the Company achieved total revenue of approximately $3.2 million. In the first half of 2024, net income increased by approximately 25.0% We have realized an improvement in our gross profit margin within our business. During the first half of 2024, the Company reported a net income of approximately $0.5 million, marking a notable increase of approximately 25.0% compared to that of approximately $0.4 million for the same period in 2023. Updates on principal sectors Professional solution services: This sector contributed approximately 31.7% of the Company’s total revenue, amounting to approximately $1.0 million. The services provided by us include (i) the secondment of senior executives such as chief financial officers and company secretaries to perform compliance, financial reporting and financial management functions for customers; (ii) the provision of accounting and audit professionals to perform audit work under the instruction of Certified Public Accountant firms; and (iii) the provision of corporate finance experts to assist in drafting of documents including circulars, announcements and others for Hong Kong listed companies and listing documents for private companies planning to go public. Nursing solution services: This sector generated approximately $0.7 million in revenue, representing approximately 21.3% of the Company’s total revenue. We provide human resources solutions to social service organizations and nursing homes by matching both temporary and permanent vacancies with candidates in our extensive talent pool. Logistics and other solution services: This sector brought in approximately $1.5 million in revenue, representing approximately 47.0% of the Company’s total revenue. We provide human resources solutions by matching workers such as packaging staff and movers from our talent pool with both temporary and permanent vacancies offered by our customers. The strong growth in revenue from this sector of approximately 72.6% reflected the rapid expansion of this sector during the six months ended June 30, 2024 in particular the additional demand for placement of works from a major customer starting in April 2024. Outlook Amid a challenging but promising market environment in Hong Kong, we will continue to focus on enhancing service quality and fulfillment capabilities to meet the ever-changing needs of our customers. Furthermore, we will actively pursue fresh business prospects to extend its market presence. Moving forward, our management holds a positive outlook on the long-term potential of the Company. About Click Holdings Limited We are a human resources solutions provider, specializing in offering comprehensive human resources solutions in three principal sectors, namely (i) professional solution services, (ii) nursing solution services, and (iii) logistics and other solution services. We are primarily focused on talent sourcing and the provision of temporary and permanent personnel to customers. Our primary market is in Hong Kong and our diverse clientele includes accounting and professional firms, Hong Kong listed companies, nursing homes, individual patients, logistics companies and warehouses. For more information on the Company and its filings, which are available for review at www.sec.gov . Safe Harbor Statement Certain statements in this announcement are forward-looking statements. These forward-looking statements involve known and unknown risks and uncertainties and are based on the Company’s current expectations and projections about future events that the Company believes may affect its financial condition, results of operations, business strategy and financial needs. Investors can identify these forward-looking statements by words or phrases such as “may,” “will,” “expect,” “anticipate,” “aim,” “estimate,” “intend,” “plan,” “believe,” “is/are likely to,” “potential,” “continue” or other similar expressions. The Company undertakes no obligation to update or revise publicly any forward-looking statements to reflect subsequent occurring events or circumstances, or changes in its expectations, except as may be required by law. Although the Company believes that the expectations expressed in these forward-looking statements are reasonable, it cannot assure you that such expectations will turn out to be correct, and the Company cautions investors that actual results may differ materially from the anticipated results and encourages investors to review other factors that may affect its future results in the Company’s registration statement and other filings with the SEC, which are available for review at www.sec.gov . For enquiry, please contact: Click Holdings Limited Unit 709, 7/F., Ocean Centre 5 Canton Road Tsim Sha Tsui, Kowloon Hong Kong Email: admin@clickholdings.com.hk Phone: +852 2691 8200

Yesterday, the United States Bureau of Labor Statistics reported that the November Producer Price Index (PPI) rose 0.4%, higher than analysts’ expectation of 0.2%. The PPI rose 3% year over year — the biggest increase since February 2023. Higher-than-expected inflation in the United States has weighed on the global equity markets, with the S&P/TSX Composite Index falling 0.96% yesterday. The ongoing geopolitical tensions and threats of tariffs are causes of concern. Given the uncertain outlook, investors can strengthen their (Tax-Free Savings Account) by adding defensive stocks to avoid a decline in their contribution room in case of a steep correction. Against this backdrop, here are my three top picks. Waste Connections ( ) is a waste management company that has expanded its footprint in the United States and Canada through organic growth and strategic acquisitions. Supported by its solid underlying businesses and growth initiatives, the company has been driving its financials and stock prices at a healthier rate. Over the last 10 years, the company has returned around 515% at an annualized rate of 19.9%. Moreover, WCN continues its organic growth and strategic acquisitions to boost its financials. It is building several renewable natural gas (RNG) and resource recovery facilities, with the management projecting 12 RNG facilities to become operational in 2026. The company is also implementing technological advancements, such as robotics, optical sorters, and AI (artificial intelligence), which could improve employees’ safety and operating efficiency. Notably, the company has raised its at an annualized rate of around 14% since 2010. Considering all these factors, I believe WCN would be an excellent addition to your TFSA. Dollarama ( ) is another excellent defensive stock to have in your portfolio due to its consistent same-store sales, irrespective of the broader market conditions. Its superior direct-sourcing model and efficient logistics system allow it to offer various consumer products at attractive prices, thus enjoying healthy footfalls even during a challenging macro environment. The company focuses on expanding its store network and expects to increase its store count from 1,601 to 2,200 by the end of fiscal 2034. Dollarama also plans to build its second logistics hub and is working on acquiring land in Calgary, Alberta, for $46.7 million. The management is projecting a capital expenditure of $450 million to construct the facility, which the management expects to commission by the end of 2027. This facility would support its growth and improve operating efficiency. Further, Dollarama owns a 60.1% stake in Dollarcity, which has also planned to expand its store network from 588 to 1,050 by the end of 2031. Dollarama also owns an option that would allow it to increase its stake in Dollarcity to 70% by the end of 2027. Considering its solid underlying business and healthy growth prospects, I believe Dollarama would be an ideal addition to your TFSA in an uncertain outlook. Hydro One ( ) is a pure-play electricity transmission and distribution company, with 99% of its business rate regulated. With no material exposure to commodity price fluctuations, the company’s financials are less susceptible to broader market conditions, thus making it an excellent defensive bet. The has been expanding its rate base at an annualized rate of 5% for the last six years, boosting its financials and cash flows. Supported by its healthy cash flows, the company has raised its dividends at a 5% CAGR (compound annual growth rate) since 2016. Moreover, the demand for electricity is rising amid government policy changes favouring electrification, technological development, and increasing income levels, thus driving the demand for Hydro One’s services. The company is also expanding its asset base, with a $11.8 billion capital investment plan that it expects to invest between 2023 and 2027. Along with these investments, its continued focus on improving operating efficiencies could allow it to boost its financials and maintain its dividend growth in the coming years.NASA Awards Test Operations ContractCardinals' sudden 3-game tailspin has turned their once solid playoff hopes into a long shot

Ashton introduces Silestone Le Chic Bohème and Dekton Pietra EditionPolice in South Wales and Gwent will become the first police units in the UK to use mobile apps with facial recognition that can scan a person’s face in “near real-time.” The app, known as operator-initiated facial recognition (OIFR), allows law enforcement to take a photograph of a person’s face with a mobile phone and match it to a predetermined database. The technology, however, has quickly come under scrutiny from rights groups that warn that police searches could be conducted against thousands of photos of innocent people. Police say that the OIFR will enable quick identification of suspects and missing persons. The facial recognition feature can also be used when a person is found unconscious or dead, refuses to identify themselves or provides a fake name. “This mobile phone app means that with the taking of a single photograph which is compared to the police database, officers can easily and quickly answer the question of ‘Are you really the person we are looking for?” says Trudi Meyrick, assistant chief constable to the South Wales Police. The app has already been tested by 70 officers across South Wales, securing quick arrests and detentions. However, digital rights group Big Brother Watch says that mobile facial recognition could create a “dangerous imbalance” between the public’s rights and the police’s powers. For years, regulators and rights groups have been that the police are storing images of innocent people in its national database which may be used for facial recognition checks. This is despite a ruling that keeping custody images of people who faced no charge or were charged and then acquitted is unlawful. “South Wales Police will search against thousands of unlawfully held photos every time they do a face scan, and they should be fixing this ongoing industrial-scale privacy breach rather than exploiting these photos for yet more surveillance,” says Jake Hurfurt, head of Research and Investigations at Big Brother Watch. According to the organization, South Wales Police has disproportionately targeted ethnic minorities for face scans, which may further undermine trust in the police. The police note that in private places such as houses, schools, medical facilities and places of worship the app will only be used in situations carrying a risk of significant harm. Photos taken through the app will not be retained. “The use of this technology always involves human decision-making and oversight,” says Gwent Police Assistant Chief Constable Nick McLain. While the UK government has been equipping police with more facial recognition surveillance tools, privacy and data watchdogs have been warning of lacking oversight. Rishi Sunak’s government had planned to eliminate the post of the Biometrics and Surveillance Camera Commissioner, transferring of the responsibilities for biometrics regulation to the Information Commissioner’s Office. However, the Data Protection and Digital Information Bill (DPDI) that was supposed to enable this change was in May due to the UK elections. Since then, England and Wales have had limited oversight, according to the Scottish Biometrics Commissioner Brian Plastow. The Home Office has been “gapping” the position since Tony Eastaugh left in mid-August, Plastow tells in an email. Eastaugh after leaving the dual-commissioner post. “At a time when the new UK Government is advocating greater use of surveillance technologies such as Live Facial Recognition, the Commissioner is now calling on the UK Government to end its paradigm of indecisiveness by appointing a Commissioner for England and Wales to restore the independent oversight,” Plastow’s office in response to the England and Wales Commissioners’ Annual Report. New forms of biometric technology are far from the only concern, however, as Plastow notes that “National Security Determinations (including in Scotland) are stacking up with no independent oversight being exercised.” | | | | | | | |Facing far-right ultimatum, French finance minister says budget can still be improved PARIS: French Finance Minister Antoine Armand said on Saturday that the 2025 budget could still be improved, but stopped short of giving ground in a standoff with the far right over new concessions. France’s budget deficit has spiralled out of control this year, pressuring French government bonds, although ratings agency Standard & Poor’s gave Prime Minister Michel Barnier’s fragile minority government a rare reprieve late on Friday by leaving its rating steady. Any relief is likely to prove short-lived with both the left and far right threatening to bring Barnier’s government down over the budget, which seeks to squeeze 60 billion euros ($64 billion) in savings through tax hikes and spending cuts. Marine Le Pen’s far right National Rally (RN), whose tacit support Barnier needs to survive a likely no confidence motion, has given him until Monday to accede to her demands to make further changes to the budget. “This government, under his authority, is willing to listen, to have a dialog, to be respectful, to improve this budget,” Armand told journalists. Asked about the showdown with Le Pen, he said: “The only ultimatum really facing the French is that our country gets a budget.” On Thursday, Barnier dropped plans to raise electricity taxes in the budget as the RN had demanded, but it is keeping pressure on the government to hike pensions in line with inflation where the government had hoped to postpone an increase to save money. RN lawmaker Jean-Philippe Tanguy told Les Echos newspaper on Saturday if the bill is not modified the party would back a no-confidence motion. The test could come as soon as Monday if Barnier’s government has to use an aggressive constitutional measure to ram the social security financing legislation through parliament, which will trigger a no-confidence motion. “The government doesn’t seem to want to move (on pensions). We are waiting to see the social security bill on Monday to draw conclusions,” Tanguy said. The RN also wants planned cuts to medication reimbursements by the state to be axed, increased taxes on share buybacks and financial transactions as well as a cut in France’s contribution to the European Union’s budget. The government’s aim to cut the budget deficit next year to 5.0 per cent of economic output from over 6.0 per cent this year is already sliding in the face of costly concessions made to the RN and other parties. Standard & Poor’s said that it expected the deficit at 5.3 per cent next year and said the outlook was unclear after that whether France could keep reducing the deficit to an EU limit of 3.0 per cent as currently planned by 2029. As the RN has firmed up its demands, French debt and stocks have come under pressure in recent days, pushing the risk premium on French government bonds to their highest level in over 12 years. “The absence of a budget (and) political instability would bring a sudden and substantial increase in the financing costs of French debt,” Armand said.

Plus Wallet Steals the Spotlight with Huge Rewards While Ripple CEO Highlights Trump’s Crypto Stance & Binance Prepares Comeback

Reilly scores 18 as Delaware downs Rider 72-66Sam Hicks, defense lead Abilene Christian over Northern Arizona 24-0 to extend 1st trip to playoffs

An elaborate parody appears to be behind an effort to resurrect Enron, the Houston-based energy company that exemplified the worst in American corporate fraud and greed after it went bankrupt in 2001. If its return is comedic, some who lost everything in Enron’s collapse aren’t laughing. “It’s a pretty sick joke and it disparages the people that did work there. And why would you want to even bring it back up again?” said former Enron employee Diana Peters, who represented workers in the company’s bankruptcy proceedings. Here’s what to know about the history of Enron and the purported effort to bring it back. Once the nation’s seventh-largest company, Enron filed for bankruptcy protection on Dec. 2, 2001, after years of accounting tricks could no longer hide billions of dollars in debt or make failing ventures appear profitable. The energy company’s collapse put more than 5,000 people out of work, wiped out more than $2 billion in employee pensions and rendered $60 billion in Enron stock worthless. Its aftershocks were felt throughout the energy sector. Twenty-four , including , were eventually convicted for their roles in the fraud. Enron founder Ken Lay’s convictions were vacated after he died of heart disease following his 2006 trial. On Monday — the 23rd anniversary of the bankruptcy filing — a company representing itself as Enron announced in a news release that it was relaunching as a “company dedicated to solving the global energy crisis.” It also posted a video on social media, advertised on at least one Houston billboard and a took out a full-page ad in the Houston Chronicle In the minute-long video that was full of generic corporate jargon, the company talks about “growth” and “rebirth.” It ends with the words, “We’re back. Can we talk?” Enron’s new website features a company store, where various items featuring the brand’s tilted “E” logo are for sale, including a $118 hoodie. In an email, company spokesperson Will Chabot said the new Enron was not doing any interviews yet, but that “We’ll have more to share soon.” Signs point to the comeback being a joke. In the “terms of use and conditions of sale” on the company’s website, it says “the information on the website about Enron is First Amendment protected parody, represents performance art, and is for entertainment purposes only.” Documents filed with the U.S. Patent and Trademark Office show that College Company, an Arkansas-based LLC, owns the Enron trademark. The co-founder of College Company is Connor Gaydos, who helped create a joke conspiracy theory that claims all birds are actually surveillance drones for the government. Peters said that since learning about the “relaunch” of Enron, she has spoken with several other former employees and they are also upset by it. She said the apparent stunt was “in poor taste.” “If it’s a joke, it’s rude, extremely rude. And I hope that they realize it and apologize to all of the Enron employees,” Peters said. Peters, who is 74 years old, said she is still working in information technology because “I lost everything in Enron, and so my Social Security doesn’t always take care of things I need done.” “Enron’s downfall taught us critical lessons about corporate ethics, accountability, and the consequences of unchecked ambition. Enron’s legacy was the employees in the trenches. Leave Enron buried,” she said. __ This story was corrected to fix the spelling of Ken Lay’s first name, which had been misspelled “Key.” ___ Follow Juan A. Lozano on X at An elaborate parody appears to be behind an effort to By most accounts, 2017 was a red-letter year for Salter’s First finalist: Moore Grider Second finalist: Janzen, Tamberi & Wong( MENAFN - The Conversation) The original excitement about the influence of artificial intelligence (AI) on developed countries is shifting toward how AI might influence developing nations. The Economist recently ran a cover story extolling the potential of AI to help lower-income countries in sectors such as education, healthcare and agriculture; however, various commentators have expressed concerns that AI could cause a number of harms in the Global South. At the root of this issue runs a frequent concern with how data is collected, stored and used – and responsibly reused for purposes other than it was initially collected for. Data collected from satellite imagery and sensors can be reused to monitor deforestation, air and water quality, and the impact of climate change . Telco or social media data can be reused for disaster response to track people's movements, identify areas that need urgent assistance and coordinate relief efforts more effectively. Responsible reuse of public and private data can also break down silos. Access to mobile phone data has been reused to foster collaboration and innovation, like harmonising access to public transport and ride-sharing initiatives to limit travel time and reduce car use. Open contracting data was used to improve access to HIV and tuberculosis medicine in Moldova, a country that has one of the highest patient rates in Europe. But reuse carries its own risks, especially to user privacy and security. Promoting the responsible reuse of data requires addressing power imbalances in the data ecology that disempower key stakeholders and undermine trust in data management practices. These imbalances may be particularly pernicious in the Global South . Addressing them requires broadening notions of consent beyond current individualised approaches in favour of what we term a social licence for reuse. There are a number of imbalances in power and influence among different stakeholders in the data ecology. Larger players or those from more affluent regions have bigger budgets and more expertise, plus more computational power, to access and work with data. These imbalances take on particular significance when data is repurposed. In such cases, original data subjects frequently lack the ability to influence or even become aware of secondary uses, and data could be used in ways that harm them or that disproportionately benefit the few. These risks are particularly pronounced in developing countries in Asia, Africa and Latin America, due in part to power imbalances between governments and companies in the Global South and North. But vast asymmetries also exist within Global South countries themselves, requiring close attention to the way data is collected, used and reused by governments that profess to speak on behalf of the people. In theory, consent offers a mechanism to reduce power imbalances. In reality, existing consent mechanisms are limited and, in many respects, archaic, based on binary distinctions – typically presented in check-the-box forms that most websites use to ask you to register for marketing e-mails – that fail to appreciate the nuance and context-sensitive nature of data reuse. Consent today generally means individual consent, a notion that overlooks the broader needs of communities and groups. While we understand the need to safeguard information about an individual such as, say, their health status, this information can help address or even prevent societal health crises. Individualised notions of consent fail to consider the potential public good of reusing individual data responsibly. This makes them particularly problematic in societies that have more collective orientations, where prioritising individual choices could disrupt the social fabric. The notion of a social licence, which has its roots in the 1990s within the extractive industries , refers to the collective acceptance of an activity, such as data reuse, based on its perceived alignment with community values and interests. Social licences go beyond the priorities of individuals and help balance the risks of data misuse and missed use (for example, the risks of violating privacy vs. neglecting to use private data for public good). Social licences permit a broader notion of consent that is dynamic, multifaceted and context-sensitive. Policymakers, citizens, health providers, think tanks, interest groups and private industry must accept the concept of a social licence before it can be established. The goal for all stakeholders is to establish widespread consensus on community norms and an acceptable balance of social risk and opportunity. Community engagement can create a consensus-based foundation for preferences and expectations concerning data reuse. Engagement could take place via dedicated“data assemblies” or community deliberations about data reuse for particular purposes under particular conditions. The process would need to involve voices as representative as possible of the different parties involved, and include those that are traditionally marginalised or silenced. Beyond community engagement, buy-in from the legal and policy community is needed to translate collective choices into enforceable instruments and mechanisms. This critical step requires innovative approaches to develop ways of framing, and vehicles to contain, new governance functions. A dedicated interdisciplinary research agenda across data, law, policy and the social sciences will help link the theory of social licensing and its practical implementation. Successfully implementing social licensing will most likely require institutional innovation as well, which could include highlighting the role of data stewards or other individuals tasked with responsibly promoting data sharing. We've seen increasing calls for the role of Chief AI Officer (CAIO) to lead integration of AI technologies to drive innovation and achieve competitive advantage. We do believe there should be a dedicated role in all fields of data collection, public and private, to identify how data may be used in an organisation. But we also believe this scope is too limited. Such a role can also include identifying opportunities based on other data that is available or should be. It can further include identifying opportunities based on an organisation's own data that may be shared – not only for profit, but also for the public good. MENAFN15122024000199003603ID1108995325 Legal Disclaimer: MENAFN provides the information “as is” without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the provider above.

CAMBRIDGE, Mass., Dec. 09, 2024 (GLOBE NEWSWIRE) -- Relay Therapeutics, Inc. (Nasdaq: RLAY), a clinical-stage precision medicine company transforming the drug discovery process by combining leading-edge computational and experimental technologies, today announced that updated clinical data for RLY-2608 600mg BID + fulvestrant in patients with PI3Kα-mutated, HR+, HER2- locally advanced or metastatic breast cancer will be presented at the upcoming San Antonio Breast Cancer Symposium, taking place December 10-13, 2024. Details of the RLY-2608 + fulvestrant poster presentation are as follows: Abstract Title : PS7-01: Efficacy of RLY-2608, a mutant-selective PI3Kα inhibitor in patients with PIK3CA-mutant HR+HER2- advanced breast cancer: ReDiscover trial Abstract Number: SESS-2211 Session : Concurrent Poster Spotlight Session 7: Targeting the ER and PI3K pathway: Novel drugs and combinations Date/Time : Wednesday, December 11, 8:00-9:30 a.m. ET (7:00-8:30 a.m. CT) Conference Call Information Relay Therapeutics will host a conference call to discuss these data on Wednesday, December 11, 2024 at 7:00 a.m. ET (6:00 a.m. CT). Registration and dial-in for the conference call and webcast may be accessed through Relay Therapeutics’ website under Events in the News & Events section through the following link: https://ir.relaytx.com/news-events/events-presentations . An archived replay of the webcast will be available following the event. The poster will be available at the start of the session on the company’s website at https://relaytx.com/publications/ . About RLY-2608 RLY-2608 is the lead program in Relay Therapeutics’ efforts to discover and develop mutant selective inhibitors of PI3Kα, the most frequently mutated kinase in all cancers, with oncogenic mutations detected in about 14% of patients with solid tumors. RLY-2608 has the potential, if approved, to address more than 300,000 patients per year in the United States, one of the largest patient populations for a precision oncology medicine. Traditionally, the development of PI3Kα inhibitors has focused on the active, or orthosteric, site. The therapeutic index of orthosteric inhibitors is limited by the lack of clinically meaningful selectivity for mutant versus wild-type (WT) PI3Kα and off-isoform activity. Toxicity related to inhibition of WT PI3Kα and other PI3K isoforms results in sub-optimal inhibition of mutant PI3Kα with reductions in dose intensity and frequent discontinuation. The Dynamo® platform enabled the discovery of RLY-2608, the first known allosteric, pan-mutant, and isoform-selective PI3Kα inhibitor, designed to overcome these limitations. Relay Therapeutics solved the full-length cryo-EM structure of PI3Kα, performed computational long time-scale molecular dynamic simulations to elucidate conformational differences between WT and mutant PI3Kα, and leveraged these insights to support the design of RLY-2608. RLY-2608 is currently being evaluated in a first-in-human trial designed to treat patients with advanced solid tumors with a PIK3CA (PI3Kα) mutation. For more information on RLY-2608, please visit here . About Relay Therapeutics Relay Therapeutics is a clinical-stage precision medicine company transforming the drug discovery process by combining leading-edge computational and experimental technologies with the goal of bringing life-changing therapies to patients. As the first of a new breed of biotech created at the intersection of complementary techniques and technologies, Relay Therapeutics aims to push the boundaries of what’s possible in drug discovery. Its Dynamo® platform integrates an array of leading-edge computational and experimental approaches designed to drug protein targets that have previously been intractable or inadequately addressed. Relay Therapeutics’ initial focus is on enhancing small molecule therapeutic discovery in targeted oncology and genetic disease indications. For more information, please visit www.relaytx.com or follow us on Twitter . Cautionary Note Regarding Forward-Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended, including, without limitation, implied and express statements regarding Relay Therapeutics’ strategy, business plans and focus; the progress and timing of the clinical development of the programs across Relay Therapeutics’ portfolio; the expected therapeutic benefits and potential efficacy and tolerability of RLY-2608, both as a monotherapy and in combination with other agents, and its other programs, including lirafugratinib as well as the clinical data for RLY-2608; the interactions with regulatory authorities and any related approvals; the potential market opportunity for RLY-2608; the cash runway projection and the expectations regarding Relay Therapeutics’ use of capital, expenses and potential cost savings. The words “may,” “might,” “will,” “could,” “would,” “should,” “plan,” “anticipate,” “intend,” “believe,” “expect,” “estimate,” “seek,” “predict,” “future,” “project,” “potential,” “continue,” “target” and similar words or expressions, or the negative thereof, are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Any forward-looking statements in this press release are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and important factors that may cause actual events or results to differ materially from those expressed or implied by any forward-looking statements contained in this press release, including, without limitation, risks associated with: the impact of global economic uncertainty, geopolitical instability and conflicts, or public health epidemics or outbreaks of an infectious disease on countries or regions in which Relay Therapeutics has operations or does business, as well as on the timing and anticipated results of its clinical trials, strategy, future operations and profitability; the delay or pause of any current or planned clinical trials or the development of Relay Therapeutics’ drug candidates; the risk that the preliminary or interim results of its preclinical or clinical trials may not be predictive of future or final results in connection with future clinical trials of its product candidates and that interim and early clinical data may change as more patient data become available and are subject to audit and verification procedures; Relay Therapeutics’ ability to successfully demonstrate the safety and efficacy of its drug candidates; the timing and outcome of its planned interactions with regulatory authorities; and obtaining, maintaining and protecting its intellectual property. These and other risks and uncertainties are described in greater detail in the section entitled “Risk Factors” in Relay Therapeutics’ most recent Annual Report on Form 10-K and Quarterly Report on Form 10-Q, as well as any subsequent filings with the Securities and Exchange Commission. In addition, any forward-looking statements represent Relay Therapeutics' views only as of today and should not be relied upon as representing its views as of any subsequent date. Relay Therapeutics explicitly disclaims any obligation to update any forward-looking statements. No representations or warranties (expressed or implied) are made about the accuracy of any such forward-looking statements. Contact: Megan Goulart 617-322-0814 mgoulart@relaytx.com Media : Dan Budwick 1AB 973-271-6085 dan@1abmedia.com

Southwest Airlines Co. Announcement: Southwest Airlines Co. Investors Are Encouraged To Contact The Rosen Law Firm About Ongoing Investigation Of Breaches Of Fiduciary Duties By The Directors And Officers LUV